What is the role of keratinocytes in the epidermis?

Keratinocytes play a crucial role in the epidermis by forming a protective barrier for the skin. These cells are primarily responsible for the synthesis of keratin, a key protein that contributes to the strength and resilience of the skin. Keratinocytes continually undergo a cycle of growth, differentiation, and sloughing off, creating a robust outer layer that protects the underlying tissues from environmental damage, pathogens, and dehydration. Their ability to form this barrier is essential for maintaining skin integrity and overall health, making them fundamental to the epidermal structure and function.