Where are Langerhans cells primarily located?

Langerhans cells are primarily located in the epidermis, which is the outermost layer of the skin. These specialized dendritic cells play a crucial role in the immune response by capturing and presenting antigens to T-cells, which is essential for initiating immune reactions to pathogens and other foreign substances that penetrate the skin.

The epidermis provides the ideal environment for Langerhans cells because it is directly exposed to external agents, allowing these cells to effectively monitor and respond to potential threats. Their strategic placement supports the skin's function as a barrier while ensuring that any immune challenges are promptly addressed.

In contrast, while other skin layers like the dermis and subcutaneous layer contain various cell types that support skin structure and function, Langerhans cells are specifically part of the epidermis, highlighting their unique role in skin immunity. The hair follicle does contain various types of cells, but Langerhans cells are not primarily located there, as their main function is tied to the epidermal layer.